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The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation

Abstract Background Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses. Yes-associated protein (YAP) is a recognized mechanically sensitive transcription facto...

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Uloženo v:
Hlavní autoři: Xuehuan Meng, Ye Zhu, Hao Tan, Baraa Daraqel, Ye Ming, Xiang Li, Guoyin Yang, Xinyi He, Jinlin Song, Leilei Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-09-01
Edice:Stem Cell Research & Therapy
Témata:
Cytoskeleton
LINC complex
Mechanotransduction
Proliferation
Tissue remodeling
YAP
On-line přístup:https://doi.org/10.1186/s13287-024-03884-0
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