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IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade

Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucidated. We tested the hypothesis that the mecha...

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Detalhes bibliográficos
Principais autores: Jean Kwun, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-10-01
coleção:Frontiers in Immunology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02323/full
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