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Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts

Doxorubicin (DOX), a widely used chemotherapeutic agent, has been linked to an increased risk of bone damage in human patients and induces bone loss in mice. DOX induces autophagy, which contributes to bone homeostasis and excess autophagy in osteoclasts (OCs), resulting in bone loss. We hypothesize...

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Principais autores: Hyun-Jung Park, Sun-Young Yoon, Jung-Nam Park, Jae-Hee Suh, Hye-Seon Choi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-07-01
Serier:Antioxidants
Fag:
autophagy
bone loss
doxorubicin
osteoclast
reactive oxygen species
Online adgang:https://www.mdpi.com/2076-3921/11/8/1476
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