Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts

Doxorubicin (DOX), a widely used chemotherapeutic agent, has been linked to an increased risk of bone damage in human patients and induces bone loss in mice. DOX induces autophagy, which contributes to bone homeostasis and excess autophagy in osteoclasts (OCs), resulting in bone loss. We hypothesize...

Descripció completa

Dades bibliogràfiques

Autors principals:	Hyun-Jung Park, Sun-Young Yoon, Jung-Nam Park, Jae-Hee Suh, Hye-Seon Choi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-07-01
Col·lecció:	Antioxidants
Matèries:	autophagy bone loss doxorubicin osteoclast reactive oxygen species
Accés en línia:	https://www.mdpi.com/2076-3921/11/8/1476
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!