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Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications

Abstract Background An adaptive design allows modifying the design based on accumulated data while maintaining trial validity and integrity. The final sample size may be unknown when designing an adaptive trial. It is therefore important to consider what sample size is used in the planning of the st...

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Principais autores: Qiang Zhang, Munyaradzi Dimairo, Steven A. Julious, Jen Lewis, Zihang Yu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-09-01
Serier:BMC Medical Research Methodology
Fag:
Adaptive design
Randomised controlled trial
Sample size estimation
Transparency
Reporting
Online adgang:https://doi.org/10.1186/s12874-024-02339-7
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