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Hypoxic regulation of insulin receptor substrate 2 gene expression is differently regulated by endoplasmic reticulum stress and hydrocortisone in normal human astrocytes and glioblastoma cells

Objective. The insulin receptor substrate 2 (IRS2) is phosphorylated by the tyrosine kinase activity of the insulin receptor and the insulin-like growth factor I (IGF-1) receptor upon receptor stimulation. It mediates insulin signaling controlling metabolism as well as cell proliferation and invasio...

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Principais autores: Minchenko Oleksandr H., Viletska Yuliia M., Abramchuk Anastasiia I., Sliusar Myroslava Y., Halkin Oleh V., Khikhlo Yevgen P., Danilovskyi Serhiy V., Luzina Olha Y., Minchenko Dmytro O.
Format: Artigo
Sprog:Inglês
Udgivet: Sciendo 2025-01-01
Serier:Endocrine Regulations
Fag:
hypoxia
hydrocortisone
tunicamycin
thapsigargin
irs2
normal human astrocytes
u87mg glioblastoma cells
Online adgang:https://doi.org/10.2478/enr-2025-0020
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