Effect of Antihypertensive Losartan on Ca²⁺ Mobilization in the Aorta of Middle-Aged Spontaneously Hypertensive Female Rats

Hypertension, a leading factor for cardiovascular diseases (CVD), is a particularly heavy burden in women during middle age, when cardioprotective hormones begin to decline. The abnormal handling of calcium (Ca²⁺) in vascular smooth muscle cells (VSMCs) leads to increased vasoconstriction...

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Principais autores:	Swasti Rastogi, Jessica Liaw, Yingnan Zhai, Tatiana Karpova, Linxia Gu, Kenia Nunes
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-11-01
Series:	Journal of Cardiovascular Development and Disease
Assuntos:	hypertension vascular dysfunction Ca<sup>2+</sup> mishandling middle-aged female losartan aortic stiffness
Acceso en liña:	https://www.mdpi.com/2308-3425/12/11/441
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