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An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds

Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This approach enabled the efficient synthesis of peptides...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hengyu Zhang, Lai Yue Chan, Huanhuan Zhang, Tao Jiang, David J. Craik, Wenqing Cai, Rilei Yu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2025-04-01
Cyfres:Marine Drugs
Pynciau:
Mynediad Ar-lein:https://www.mdpi.com/1660-3397/23/4/168
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!