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An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds

Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This approach enabled the efficient synthesis of peptides...

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Autors principals: Hengyu Zhang, Lai Yue Chan, Huanhuan Zhang, Tao Jiang, David J. Craik, Wenqing Cai, Rilei Yu
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2025-04-01
Col·lecció:Marine Drugs
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Accés en línia:https://www.mdpi.com/1660-3397/23/4/168
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