Curcumin and ferulic acid activate PPARγ–PGC1α signaling and improve mitochondrial function in a 6-OHDA-induced Parkinson’s cellular model

Abstract Parkinson’s disease (PD) involves mitochondrial dysfunction and oxidative stress. Curcumin (CUR) and ferulic acid (FA) are phenolic compounds with neuroprotective effects, but their roles in improving mitochondrial function in PD remain poorly understood. This study explores the neuroprotec...

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Principais autores:	Samira Hassani, Zakiyeh Tashakkor, Abolghasem Esmaeili, Kamran Ghaedi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-04-01
Series:	Scientific Reports
Assuntos:	Curcumin Ferulic acid PPARγ-PGC1α signaling Mitochondrial function 6-OHDA Parkinson’s disease
Acceso en liña:	https://doi.org/10.1038/s41598-026-49716-4
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