Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular carcinoma (HCC). However, the suppressive microenvironment and individu...

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Autori principali:	Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-04-01
Serie:	Journal of Translational Medicine
Soggetti:	HCC Nanoparticle Nanobody Phage display Nb-derived CAR-T cell therapy
Accesso online:	https://doi.org/10.1186/s12967-024-05159-x
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