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A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

ABSTRACT The cGAS‐STING pathway, a critical cytosolic DNA‐sensing mechanism in innate immunity, holds significant promise for cancer immunotherapy. However, conventional DNA‐damaging therapies lack tumor specificity and cause damage to normal tissue. Furthermore, dendritic cells (DCs), central to th...

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Main Authors: Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang
Format: Artigo
Language:Inglês
Published: Wiley 2026-03-01
Series:Advanced Science
Subjects:
cGAS‐STING pathway
immunotherapy
nanoparticles
telomere stress
TIM‐3 blockade
Online Access:https://doi.org/10.1002/advs.202518356
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