A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

ABSTRACT The cGAS‐STING pathway, a critical cytosolic DNA‐sensing mechanism in innate immunity, holds significant promise for cancer immunotherapy. However, conventional DNA‐damaging therapies lack tumor specificity and cause damage to normal tissue. Furthermore, dendritic cells (DCs), central to th...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2026-03-01
Rangatū:	Advanced Science
Ngā marau:	cGAS‐STING pathway immunotherapy nanoparticles telomere stress TIM‐3 blockade
Urunga tuihono:	https://doi.org/10.1002/advs.202518356
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!