Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway

Mitochondrial abnormality is one of the main factors of tubular injury in diabetic nephropathy (DN). Formononetin (FMN), a novel isoflavonoid isolated from Astragalus membranaceus, has diverse pharmacological activities. However, the beneficial effects of FMN on renal tubular impairment and mitochon...

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Principais autores:	Qunwei Huang, Hongbo Chen, Kai Yin, Yilan Shen, Kanghong Lin, Xieyi Guo, Xiang Zhang, Niansong Wang, Wenfeng Xin, Youhua Xu, Dingkun Gui
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Pharmacology
Assuntos:	diabetic nephropathy formononetin tubular injury mitochondrial dynamics Sirt1/PGC-1α
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fphar.2022.901234/full
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