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Structural patterns and transcriptional effects of integrated Epstein-Barr Virus revealed by long-read sequencing and RNA-sequencing in nasopharyngeal carcinoma

Abstract Integration of Epstein–Barr virus (EBV) DNA into the human genome is a critical event in nasopharyngeal carcinogenesis. Here, we comprehensively characterize large-scale virus-human integration events in three EBV-positive nasopharyngeal carcinoma (NPC) cell lines and one patient NPC tumor...

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Principais autores: Zahra Kardan, Adway Kadam, Annie Wai Yeeng Chai, Sok Ching Cheong, Sampath Kumar Loganathan
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2026-05-01
סדרה:Virology Journal
נושאים:
Epstein-Barr virus (EBV)
Nasopharyngeal carcinoma (NPC)
Long-read sequencing
Oxford Nanopore
EBV fusions
גישה מקוונת:https://doi.org/10.1186/s12985-026-03196-0
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