Structural patterns and transcriptional effects of integrated Epstein-Barr Virus revealed by long-read sequencing and RNA-sequencing in nasopharyngeal carcinoma

Abstract Integration of Epstein–Barr virus (EBV) DNA into the human genome is a critical event in nasopharyngeal carcinogenesis. Here, we comprehensively characterize large-scale virus-human integration events in three EBV-positive nasopharyngeal carcinoma (NPC) cell lines and one patient NPC tumor...

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Hlavní autoři:	Zahra Kardan, Adway Kadam, Annie Wai Yeeng Chai, Sok Ching Cheong, Sampath Kumar Loganathan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Virology Journal
Témata:	Epstein-Barr virus (EBV) Nasopharyngeal carcinoma (NPC) Long-read sequencing Oxford Nanopore EBV fusions
On-line přístup:	https://doi.org/10.1186/s12985-026-03196-0
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