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BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progression.

INTRODUCTION:Brain-Derived Neurotrophic Factor (BDNF) and its most common polymorphism Val66Met are known to have a role in Multiple Sclerosis (MS) pathogenesis. Evidence is accumulating that there is an involvement of DNA methylation in the regulation of BDNF expression. The aim of this study was t...

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Main Authors: Viviana Nociti, Massimo Santoro, Davide Quaranta, Francesco Antonio Losavio, Chiara De Fino, Rocco Giordano, Nicole Piera Palomba, Paolo Maria Rossini, Franca Rosa Guerini, Mario Clerici, Domenico Caputo, Massimiliano Mirabella
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6198951?pdf=render
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