The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor (BDNF) is a common genetic variant that can alter therapeutic responses in individuals with Parkinson’s disease...

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Autors principals:	Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-01-01
Col·lecció:	Neurobiology of Disease
Matèries:	Parkinson’s disease Neural grafting Val66Met Val68Met rs6265 BDNF
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996120304502
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