Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age

In the past 25 years, the prevalence of Parkinson's disease (PD) has nearly doubled. Age remains the primary risk factor for PD and as the global aging population increases this trend is predicted to continue. Even when treated with levodopa, the gold standard dopamine (DA) replacement therapy, indi...

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Detalhes bibliográficos

Principais autores:	Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-06-01
coleção:	Neurobiology of Disease
Assuntos:	Parkinson's disease CaV1.3 channels Gene therapy Levodopa-induced dyskinesia Striatum Adeno-associated virus (AAV)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996123001250
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