Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells

Objective: Pancreatic beta-cells express three Munc18 isoforms. Much is known about the roles of Munc18a (pre-docked secretory granules-SGs) and Munc18b (newcomer SGs and SG–SG fusion) in insulin exocytosis. Although shown to influence glucose-stimulated insulin secretion (GSIS) in rodents the preci...

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Auteurs principaux:	Dan Zhu, Li Xie, Negar Karimian, Tao Liang, Youhou Kang, Ya-Chi Huang, Herbert Y. Gaisano
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2015-05-01
Collection:	Molecular Metabolism
Sujets:	Munc18c Exocytosis Newcomer insulin granules Human islets
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S221287781500040X
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