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Septin5 deletion enhances β-cell exocytosis by releasing microtubule-tethered insulin granules onto plasma membrane
Abstract Septin5 interacts with SNARE proteins to regulate exocytosis in neurons, but its role in pancreatic β-cells is unknown. Here, we report that Septin5 is abundant in rodent and human β-cells, deletion of which dramatically enhances biphasic glucose-stimulated insulin secretion, including in t...
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| Main Authors: | , , , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Portfolio
2025-03-01
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| Sraith: | Nature Communications |
| Rochtain Ar Líne: | https://doi.org/10.1038/s41467-025-57421-5 |
| Clibeanna: |
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