Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer

Cancer-associated fibroblasts (CAFs) exert a key role in cancer progression and liver metastasis. They are activated in the tumor microenvironment (TME), but their prometastatic mechanisms are not defined. CAFs are abundant in colorectal cancer (CRC). However, it is not clear whether they are raised...

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Detalhes bibliográficos

Principais autores:	Mengxuan Yang, Zhuang Wei, Mei Feng, Yuanyuan Zhu, Yong Chen, Di Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Oncology
Assuntos:	colorectal cancer cancer-associated fibroblasts Wnt signaling BCL9 tumor immune microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2021.603556/full
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