Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

Summary: Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we exposed induced cranial and spinal motor neurons (iCrMNs and iSpMNs) to proteotoxic stress, under which iCrMNs showed...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Ana Paula Zen Petisco Fiore, Shuvadeep Maity, Lauren Jeffery, Disi An, Justin Rendleman, Dylan Iannitelli, Hyungwon Choi, Esteban Mazzoni, Christine Vogel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-03-01
Serie:	Cell Reports
Soggetti:	motor neurons amyotrophic lateral sclerosis Ublcp1 unfolded protein response proteasome
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124724002134
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!