Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm
Background cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley
2022-01-01
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| Col·lecció: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Matèries: | |
| Accés en línia: | https://www.ahajournals.org/doi/10.1161/JAHA.121.023053 |
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