Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm

Background cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Chongyang Zhang, Amy Mohan, Hangchuan Shi, Chen Yan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2022-01-01
Schriftenreihe:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Schlagworte:	abdominal aortic aneurysm elastase elastin degradation sildenafil Viagra
Online-Zugang:	https://www.ahajournals.org/doi/10.1161/JAHA.121.023053
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!