Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

In this study the effect of eight DNA topoisomerase inhibitors on the growth Trypanosoma rangeli epimastigotes in cell culture was investigated. Among the eight compounds tested, idarubicin was the only compound that displayed promising trypanocidal activity with a half-maximal growth inhibition (GI...

Descripció completa

Dades bibliogràfiques

Autors principals:	Momodou Jobe, Charles Anwuzia-Iwegbu, Ama Banful, Emma Bosier, Mubeen Iqbal, Kelly Jones, Suzanne J Lecutier, Kasimir Lepper, Matt Redmond, Andrew Ross-Parker, Emily Ward, Paul Wernham, Eleanor M Whidden, Kevin M Tyler, Dietmar Steverding
Format:	Artigo
Idioma:	Inglês
Publicat:	Fundação Oswaldo Cruz (FIOCRUZ) 2012-11-01
Col·lecció:	Memorias do Instituto Oswaldo Cruz
Matèries:	Trypanosoma rangeli Trypanosoma cruzi Chagas disease DNA topoisomerase inhibitors drug screening chemotherapy
Accés en línia:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700018&lng=en&tlng=en
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!