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In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytoto...

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Autori principali: Stefânia Neiva Lavorato, Policarpo Ademar Sales Júnior, Silvane Maria Fonseca Murta, Alvaro José Romanha, Ricardo José Alves/
Natura: Artigo
Lingua:Inglês
Pubblicazione: Fundação Oswaldo Cruz (FIOCRUZ) 2015-06-01
Serie:Memorias do Instituto Oswaldo Cruz
Soggetti:
Trypanosoma cruzi
antitrypanosomal agents
Chagas disease
1,3-bisaryloxypropanamines
Accesso online:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566&lng=en&tlng=en
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