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TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

ABSTRACT Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) ind...

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Principais autores: Lucy Cassar, Craig Nicholls, Alex R. Pinto, Ruping Chen, Lihui Wang, He Li, Jun-Ping Liu
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016-09-01
Serier:Protein & Cell
Fag:
BMPRII
TGFbeta
hTERT
telomerase
telomeres
senescence
Online adgang:http://link.springer.com/article/10.1007/s13238-016-0322-1
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