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The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.

Pyruvate is a metabolic fuel that is a potent inotropic agent. Despite its unique inotropic and antioxidant properties, the molecular mechanism of its inotropic mechanism is still largely unknown. To examine the inotropic effect of pyruvate in parallel with intracellular calcium handling under near...

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Principais autores: Carlos A A Torres, Kenneth D Varian, Cynthia H Canan, Jonathan P Davis, Paul M L Janssen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3655183?pdf=render
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