DNA double-strand break-free CRISPR interference delays Huntington’s disease progression in mice
Abstract Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. CRISPR-Cas9 nuclease causes double-strand breaks (DSBs) in the targeted DNA that induces toxicity, whereas CRISPR interference (CRISPRi) using dead Cas9 (dCas9) suppresses the target gene expression...
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| Huvudupphov: | , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
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Nature Portfolio
2023-04-01
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| Serie: | Communications Biology |
| Länkar: | https://doi.org/10.1038/s42003-023-04829-8 |
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