The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs
<i>Plasmodium</i> has evolved to regulate the levels and oxidative states of iron protoporphyrin IX (Fe-PPIX). Antimalarial endoperoxides such as 1,2,4-trioxane artemisinin and 1,2,4-trioxolane arterolane undergo a bioreductive activation step mediated by heme (FeII-PPIX) but not by hematin (FeIII-P...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
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MDPI AG
2022-01-01
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| Serier: | Pharmaceuticals |
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| Online adgang: | https://www.mdpi.com/1424-8247/15/1/60 |
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