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Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

The development of universal influenza vaccines has been a priority for more than 20 years. We conducted a preclinical study in ferrets of two sets of live attenuated influenza vaccines (LAIVs) expressing chimeric hemagglutinin (cHA). These vaccines contained the HA stalk domain from H1N1pdm09 virus...

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Principais autores: Irina Isakova-Sivak, Victoria Matyushenko, Tatiana Kotomina, Irina Kiseleva, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Natalia Larionova, Daria Mezhenskaya, Konstantin Sivak, Arman Muzhikyan, Anastasia Katelnikova, Larisa Rudenko
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-07-01
coleção:Vaccines
Assuntos:
universal influenza vaccine
chimeric hemagglutinin
nucleoprotein
live attenuated influenza vaccine
sequential immunization
ferret model
Acesso em linha:https://www.mdpi.com/2076-393X/7/3/61
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