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Coordination of transcription-coupled repair and repair-independent release of lesion-stalled RNA polymerase II

Abstract Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (Pol II), which then initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery. In the absence of TCR, eviction of lesion-stalled Pol II is required for alternative pathways to addres...

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Hlavní autoři: Yongchang Zhu, Xiping Zhang, Meng Gao, Yanchao Huang, Yuanqing Tan, Avital Parnas, Sizhong Wu, Delin Zhan, Sheera Adar, Jinchuan Hu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2024-08-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-024-51463-x
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