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Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B

Abstract The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal period (γ to β). The γ- to β-globin gene switching mechan...

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Principais autores: Petros Papadopoulos, Athanassia Kafasi, Iris M. De Cuyper, Vilma Barroca, Daniel Lewandowski, Zahra Kadri, Martijn Veldthuis, Jeffrey Berghuis, Nynke Gillemans, Celina María Benavente Cuesta, Frank G. Grosveld, Rob van Zwieten, Sjaak Philipsen, Muriel Vernet, Laura Gutiérrez, George P. Patrinos
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-10-01
Serier:Human Genomics
Fag:
Dyserythropoiesis
Hemoglobin switching
Hereditary persistence of fetal hemoglobin (HPFH)
Thalassemia
Gene expression
Erythropoiesis
Online adgang:http://link.springer.com/article/10.1186/s40246-020-00283-3
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