ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. In this study, we used kidney-specific expression of quantitative traits and single-nucleus open chromatin analysis to show that genetic variants...
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| Hoofdauteurs: | , , , , , , , , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2024-02-01
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| Reeks: | The Journal of Clinical Investigation |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1172/JCI172963 |
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