ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD) remain incompletely understood. Using quantitative histone proteomics in murine fibrosis models, we uncovered a selective increase in  histone H3 lysine 27 acetylation (H3K2...

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Principais autores:	Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2026-07-01
Serija:	Advanced Science
Teme:	acetyl‐CoA metabolism chromatin accessibility H3K27ac kidney fibrosis
Online dostop:	https://doi.org/10.1002/advs.75247
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