Personalized medicine strategy for MPNSTs: using precision oncology on PDOX models to inform tumor boards

Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) are a heterogeneous group of aggressive soft tissue sarcomas with poor prognosis. Currently there is a lack of effective treatments for MPNSTs. Here, we propose a personalized medicine approach that integrates a precision oncology...

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Bibliografiske detaljer

Principais autores:	Sara Ortega-Bertran, Juana Fernández-Rodríguez, Miriam Magallón-Lorenz, Edgar Creus-Bachiller, Itziar Uriarte-Arrazola, Helena Mazuelas, Moira Garraus, Meritxell Carrió, Bernat Gel, Carlota Rovira, Mariana Alvarez, Alberto Villanueva, Alicia Castaneda, Héctor Salvador, Eduard Serra, Conxi Lázaro
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2026-02-01
Serier:	Journal of Translational Medicine
Fag:	Malignant peripheral nerve sheath tumor MPNST PDX Neurofibromatosis type 1 WGS Personalized treatment
Online adgang:	https://doi.org/10.1186/s12967-026-07751-9
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