Induced pluripotent stem cell–derived models of malignant nerve sheath tumor progression mimic glial to neuro-mesenchymal transition and uncover therapeutic opportunities

Abstract Neurofibromatosis Type 1 (NF1) predisposes to peripheral nerve tumor development. The progression from a benign plexiform neurofibroma (PNF) towards a deadly malignant peripheral nerve sheath tumor (MPNST) is not completely understood but commonly involves the sequential loss of NF1, CDKN2A...

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Prif Awduron:	Itziar Uriarte-Arrazola, Míriam Magallón-Lorenz, Juana Fernández-Rodríguez, Jiajing Zhang, Emily Lee, Sara Ortega-Bertran, Edgar Creus-Bachiller, Judit Farrés-Casas, Kelli M. Wilson, Crystal McKnight, Katlin Recabo, Ignacio Blanco, Héctor Salvador, Cleofé Romagosa, Conxi Lázaro, Helena Mazuelas, Bernat Gel, Marc Ferrer, Meritxell Carrió, Eduard Serra
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-06-01
Cyfres:	Nature Communications
Mynediad Ar-lein:	https://doi.org/10.1038/s41467-026-73119-8
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