Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes

Autoantibodies targeting islet antigen 2 (IA2) are critical diagnostic and prognostic markers for type 1 diabetes (T1D). Standard clinical assays do not differentiate between IgG and IgM isotypes, yet these antibodies have distinct roles in the T1D autoimmunity. We therefore adapted electrochemilumi...

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Autors principals:	Xuming Mao, Jake Konigsberg, Nadia Noorchashm, Wenzhao Meng, James J. Knox, Gregory J. Golden, Jacob T. Hamilton, Tara K. Maxwell, Chengyang Liu, Michael R. Betts, Steven M. Willi, Ali Naji, Patrick Hanley, Eline T. Luning Prak
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-03-01
Col·lecció:	Biomolecules
Matèries:	type 1 diabetes (T1D) autoantibodies islet antigen 2 (IA2) Immunoglobulin G (IgG) Immunoglobulin M (IgM) electrochemiluminescence (ECL)
Accés en línia:	https://www.mdpi.com/2218-273X/16/4/500
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