Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes

Autoantibodies targeting islet antigen 2 (IA2) are critical diagnostic and prognostic markers for type 1 diabetes (T1D). Standard clinical assays do not differentiate between IgG and IgM isotypes, yet these antibodies have distinct roles in the T1D autoimmunity. We therefore adapted electrochemilumi...

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Autori principali:	Xuming Mao, Jake Konigsberg, Nadia Noorchashm, Wenzhao Meng, James J. Knox, Gregory J. Golden, Jacob T. Hamilton, Tara K. Maxwell, Chengyang Liu, Michael R. Betts, Steven M. Willi, Ali Naji, Patrick Hanley, Eline T. Luning Prak
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-03-01
Serie:	Biomolecules
Soggetti:	type 1 diabetes (T1D) autoantibodies islet antigen 2 (IA2) Immunoglobulin G (IgG) Immunoglobulin M (IgM) electrochemiluminescence (ECL)
Accesso online:	https://www.mdpi.com/2218-273X/16/4/500
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