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MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

<p>Abstract</p> <p>Background</p> <p>During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid production of type I interferons...

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Principais autores: Castanier Céline, Zemirli Naima, Portier Alain, Garcin Dominique, Bidère Nicolas, Vazquez Aimé, Arnoult Damien
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-05-01
Serier:BMC Biology
Fag:
MAVS
RIG-I-like receptors
TRIM25
ubiquitination
Online adgang:http://www.biomedcentral.com/1741-7007/10/44
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