MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

<p>Abstract</p> <p>Background</p> <p>During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid production of type I interferons...

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Autores principales:	Castanier Céline, Zemirli Naima, Portier Alain, Garcin Dominique, Bidère Nicolas, Vazquez Aimé, Arnoult Damien
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2012-05-01
Colección:	BMC Biology
Materias:	MAVS RIG-I-like receptors TRIM25 ubiquitination
Acceso en línea:	http://www.biomedcentral.com/1741-7007/10/44
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