BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity

Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether BRCA1 deficiency in non-breast somatic cells also contribute to tumorigen...

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Detalles Bibliográficos

Principais autores:	Rong Li, Xiaowen Zhang, Bogang Wu, Yanfen Hu, Anelia Horvath, Claudine Isaacs, Yidong Chen, Leilei Qi, Huai-Chin Chiang, Haihui Pan, Alexandra Greenbaum, Elizabeth Stark, Li-Ju Wang, Bassem R. Haddad, Dionyssia Clagett, Richard Elledge
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMJ Publishing Group 2023-02-01
Series:	Journal for ImmunoTherapy of Cancer
Acceso en liña:	https://jitc.bmj.com/content/11/2/e005852.full
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