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Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD

Abstract Abnormal cytoplasmic localization and accumulation of pathological transactive response DNA binding protein of 43 kDa (TDP-43) underlies several devastating diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). A key ele...

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Main Authors: Elodie Chevalier, Mickael Audrain, Monisha Ratnam, Romain Ollier, Aline Fuchs, Kasia Piorkowska, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina, Tariq Afroz
Format: Artigo
Language:Inglês
Published: BMC 2024-10-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
Spreading
Neuropathology
Immunotherapy
Pathomechanism
ALS
Online Access:https://doi.org/10.1186/s40478-024-01867-z
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