Clindamycin demonstrates clinical effectiveness for bacteremic M1UK Streptococcus pyogenes pneumonia: A case report and in vitro evidence of notable antitoxin effects on M1UK

We report a case of bacteremic M1UK Streptococcus pyogenes pneumonia in an immunocompetent patient, which improved with adjunctive clindamycin therapy. In vitro, clindamycin consistently suppressed expression of streptococcal pyrogenic exotoxin A (speA) in M1UK strains but not in the M1global strain...

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Autors principals:	Masayoshi Ezaki, Tien Manh Nguyen, Hitoshi Kawasuji, Kentaro Nagaoka, Yusuke Takegoshi, Kaho Ikeda, Junichi Kanatani, Kazunori Oishi, Yoshitomo Morinaga, Yoshihiro Yamamoto
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-07-01
Col·lecció:	International Journal of Infectious Diseases
Matèries:	Streptococcus pyogenes M1UK speA Antitoxin effect Clindamycin
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1201971226003772
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