Clindamycin demonstrates clinical effectiveness for bacteremic M1UK Streptococcus pyogenes pneumonia: A case report and in vitro evidence of notable antitoxin effects on M1UK

We report a case of bacteremic M1UK Streptococcus pyogenes pneumonia in an immunocompetent patient, which improved with adjunctive clindamycin therapy. In vitro, clindamycin consistently suppressed expression of streptococcal pyrogenic exotoxin A (speA) in M1UK strains but not in the M1global strain...

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Hlavní autoři:	Masayoshi Ezaki, Tien Manh Nguyen, Hitoshi Kawasuji, Kentaro Nagaoka, Yusuke Takegoshi, Kaho Ikeda, Junichi Kanatani, Kazunori Oishi, Yoshitomo Morinaga, Yoshihiro Yamamoto
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-07-01
Edice:	International Journal of Infectious Diseases
Témata:	Streptococcus pyogenes M1UK speA Antitoxin effect Clindamycin
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1201971226003772
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