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Dual-mode immunotherapy: ultrasound responsive zinc-based nano-contract agents synergistically activate the GAS-STING pathway for enhanced tumor sono-metalloimmunotherapy

Triple-negative breast cancer has previously been considered to a weak tumor immunogenicity. A strategy combining sono-immunotherapy and metal ion interference therapy holds promise for the tumor immune environment. 2,2-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH), functioning as a so...

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Wedi'i Gadw mewn:
Prif Awduron: Xinyu Zeng, Xiaoxuan Wang, Yading Zhao, Lu Guo, Xiao Sun, Mengmeng Shang, Shuting Huang, Rui Liu, Jialu Zhang, Shan Xiao, Dandan Shi, Ning Cong, Jie Li
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2025-09-01
Cyfres:Ultrasonics Sonochemistry
Pynciau:
Sono-metalloimmunotherapy
Acoustic cavitation
Ultrasonic imaging
STING pathway
Immunogenic cell death
mtDNA release
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S1350417725002731
Tagiau: Ychwanegu Tag
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