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Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy

Abstract Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activation pathways, which impaired their ability to trig...

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Main Authors: Shanshan Ma, Xuequan Zhang, Xiaoqi Zhu, Kangning Yan, Qin Wang, Lei Lei, Jiasheng Li, Jing Guo, Weizhong Tang, Junjie Liu, Jun Cao, Duo Wang, Tao Luo
Format: Artigo
Language:Inglês
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
cGAS-STING
Quercetin
Manganese ions
Photothermal therapy
Metalloimmunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03336-8
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