Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling

Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, a medication that also acts as an inhibitor of oxidative phosphorylation (OXPHOS), and MCL-1 inhibitor S63845 in AML cell lin...

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Auteurs principaux:	Giedrė Valiulienė, Aida Vitkevičienė, Giedrė Skliutė, Veronika Borutinskaitė, Rūta Navakauskienė
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-04-01
Collection:	Molecules
Sujets:	acute myeloid leukemia (AML) metformin MCL-1 inhibitor S63845 reactive oxygen species (ROS)
Accès en ligne:	https://www.mdpi.com/1420-3049/26/8/2303
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