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Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies

Abstract Cancer immunotherapy has reshaped the landscape of cancer treatment over the past decades. Genetic manipulation of T cells to express synthetic receptors, known as chimeric antigen receptors (CAR), has led to the creation of tremendous commercial and therapeutic success for the treatment of...

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Autors principals: Fatemeh Nasiri, Pouya Safarzadeh Kozani, Faeze Salem, Maral Mahboubi Kancha, Setareh Dashti Shokoohi, Pooria Safarzadeh Kozani
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-02-01
Col·lecció:Cancer Cell International
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Accés en línia:https://doi.org/10.1186/s12935-025-03697-y
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